Substrate trajectory through phospholipid transporting P4‐ATPases
Amherst College Digital Collections > The Octagon
| Creator | Williamson, Patrick L. |
|---|---|
| Title | Substrate trajectory through phospholipid transporting P4‐ATPases |
| Abstract | A difference in the lipid composition between the two leaflets of the simple instance of lipid compositional heterogeneity. The large activation energy barrier for transbilayer movement for some (but not all) membrane lipids creates a regime governed by active transport processes. An early step in eukaryote evolution was the development of a capacity for generating transbilayer compositional heterogeneity far from equilibrium by directly tapping energy from the ATP pool. The mechanism of the P‐type ATPases that create lipid asymmetry is well understood in terms of ATP hydrolysis, but the trajectory taken by the phospholipid substrate through the enzyme is a matter of current active research. There are currently three different models for this trajectory, all with support by mutation/activity measurements and analogies with known atomic structures. |
| Publication Date | October 1, 2014 |
| Identifier (DOI) | 10.1042/BST20140137 |
| Citation | Williamson, Patrick. “Substrate Trajectory through Phospholipid-Transporting P4-ATPases.” Biochemical Society Transactions 42.5 (2014): 1367–1371. |
| Languages | English |
| Edition | Author's Final Version |
| Genre | Articles |
| Subject | Phospholipids |
| Part of | The Amherst College Octagon |
| Repository | The Amherst College Octagon |
| Access and Use | Creative Commons Attribution-NonCommercial-NoDerivatives license (CC BY NC ND 4.0) |